Intermediate conformations during viral fusion glycoprotein structural transition
نویسندگان
چکیده
منابع مشابه
Characterization of Monomeric Intermediates during VSV Glycoprotein Structural Transition
Entry of enveloped viruses requires fusion of viral and cellular membranes, driven by conformational changes of viral glycoproteins. Crystal structures provide static pictures of pre- and post-fusion conformations of these proteins but the transition pathway remains elusive. Here, using several biophysical techniques, including analytical ultracentrifugation, circular dichroïsm, electron micros...
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Infection by enveloped viruses is initiated by the fusion of viral and cellular membranes. In many cases, the viral membrane proteins that mediate fusion must undergo conformational changes to become active. Influenza hemagglutinin, for example, is activated by a dramatic conformational rearrangement, triggered by the low pH of the intracellular compartment in which fusion occurs. Structural ch...
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ژورنال
عنوان ژورنال: Current Opinion in Virology
سال: 2013
ISSN: 1879-6257
DOI: 10.1016/j.coviro.2013.03.006